Ian R. Tizard The Immunology of the Cat makes available the first single-source, comprehensive review of the feline immune system, reporting on all immunologic aspects of diseases of the cat and its relatives and relating recent basic science to important clinical issues. The book opens with the evolution, domestication, and development of the cat then provides detailed information on immunity to infectious diseases, feline allergic diseases, the top feline autoimmune diseases, and feline immunodeficiencies. Content examines feline vaccines, hypersensitivity, cancer, nutrition, and the aged cat. Professionals in veterinary research and practice will appreciate complete information on all aspects of feline immunology in one essential resource. Read more Table of contents Cover image Title page Table of Contents Copyright Dedication Acknowledgments Introduction Chapter 1. The evolution and domestication of the cat The origins of the Feliformes The domestication of the cat Cat breeds Chapter 2. Feline ontogeny, reproduction, and lactation Feline pregnancy Ontogeny of the immune system Feline colostrum Failure of passive transfer Duration of maternal immunity Chapter 3. Innate immunity in cats Sentinel cells Pattern recognition receptors Inflammasomes Antimicrobial peptides The feline complement system Chapter 4. Feline leukocytes and erythrocytes Leukocytes Extracellular traps Erythrocytes Blood transfusions Hemolytic disease of the newborn Parentage testing Blood typing Chapter 5. The feline sickness response Effects on the brain Effects on the liver Protein misfolding diseases Inflammatory disease syndromes Chapter 6. Feline cytokines, chemokines, and interferons Inflammatory cytokines Regulatory cytokines T-cell products Other inflammatory cytokines Chemokines Interferons Cytokine receptors Chapter 7. Feline antigen presenting cells: Dendritic cells and macrophages Dendritic cells Feline macrophages B-cells Antigen processing Histiocytosis and histiocytomas Chapter 8. The feline lymphoid system Sources of lymphocytes Primary lymphoid organs Secondary lymphoid organs Chapter 9. The feline major histocompatibility complex Major histocompatibility complex FLA class I region FLA class I molecules FLA class II region FLA class II molecules FLA class III region MHC molecules and feline diseases Chapter 10. Feline innate lymphoid cells Innate helper cells Natural killer cells NK cell receptors Effector mechanisms NKT cells Chapter 11. Feline humoral immunity B-cell antigen receptors Feline heavy chains Feline light chains B-cell responses B-cell activation Plasma cells Memory B-cells Germinal centers Myelomas and plasmacytomas Immunoglobulins Chapter 12. Feline T-cells and cell-mediated immunity T cells T-cell antigen receptors T-cell activation Helper T-cells Cytotoxic T-cells T-cell regulation Regulatory T-cells Th17 cells Memory T-cells Chapter 13. Immunity on feline body surfaces The skin Respiratory tract Urogenital tract Gastrointestinal tract Mucosal lymphoid tissues Adaptive immunity Food tolerance Chapter 14. The feline microbiota and dysbiosis The evolution of carnivory The hygiene hypothesis The normal feline microbiota The skin The respiratory tract The genitourinary system The gastrointestinal tract Feline inflammatory bowel diseases Dysbiosis Chapter 15. Feline vaccines Antibacterial vaccines Antiviral vaccines Other important vaccines Immunocontraception Cat allergen vaccines Maternal antibodies Special management issues Adverse events Chapter 16. Selected feline infectious diseases Antibacterial immunity Immunity to fungi Immunity to viruses Feline coronaviruses Immune responses Chapter 17. Immunity to selected feline parasites Immunity to protozoa Immunity to helminths Immunity to arthropods Fleas Mosquitos Ticks Chapter 18. Feline anaphylaxis and allergic diseases The hygiene hypothesis Feline IgE Feline anaphylaxis Feline asthma Feline atopic skin syndrome Feline parasite allergies Feline food allergies Feline drug allergies Additional information Chapter 19. Feline eosinophilic diseases Eosinophil contents Eosinophil activation Eosinophilic granuloma complex Other eosinophilic diseases Chapter 20. Feline hypersensitivity diseases Localized type III hypersensitivity lesions Systemic type III hypersensitivity reactions Feline vasculitis Glomerulonephritis Type IV hypersensitivities Further information Chapter 21. Cancer immunology and immunotherapy The cancer immunity cycle Tumor immunotherapy Passive immunization Active immunization Feline lymphoid tumors Feline leukemia Feline injection site sarcomas Chapter 22. Feline inflammatory diseases Sterile nodular panniculitis Feline idiopathic cystitis Feline chronic gingivostomatitis Feline triaditis Immune-mediated arthritis Erosive polyarthritis Nonerosive arthritis Neurologic diseases Further information Chapter 23. Feline autoimmune diseases Autoimmune endocrine diseases Autoimmune neurological disease Autoimmune skin diseases Hair follicle diseases Autoimmune blood diseases Lymphocytic cholangitis Autoimmune muscle diseases Systemic lupus erythematosus Discoid lupus erythematosus Relapsing polychondritis Further information Chapter 24. Feline immunodeficiency diseases Primary immunodeficiencies Secondary immunodeficiencies Chapter 25. Nutrition and the feline immune system Measuring immune function Carnivory and its adaptations Antioxidants Starvation Chapter 26. Immunity in the geriatric cat Innate immunity Obesity Lymphoid organs Adaptive immunity The aged microbiota Abbreviations Index